<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tanvir Ahmed</style></author><author><style face="normal" font="default" size="100%">Sai Krupa Das</style></author><author><style face="normal" font="default" size="100%">Julie K Golden</style></author><author><style face="normal" font="default" size="100%">Edward Saltzman</style></author><author><style face="normal" font="default" size="100%">Susan B Roberts</style></author><author><style face="normal" font="default" size="100%">Simin Nikbin Meydani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Calorie restriction enhances T-cell-mediated immune response in adult overweight men and women</style></title><secondary-title><style face="normal" font="default" size="100%">The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Body Mass Index</style></keyword><keyword><style  face="normal" font="default" size="100%">Caloric Restriction</style></keyword><keyword><style  face="normal" font="default" size="100%">Delayed</style></keyword><keyword><style  face="normal" font="default" size="100%">Dinoprostone</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypersensitivity</style></keyword><keyword><style  face="normal" font="default" size="100%">Lymphocyte Activation</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Overweight</style></keyword><keyword><style  face="normal" font="default" size="100%">Sex Characteristics</style></keyword><keyword><style  face="normal" font="default" size="100%">{T-Lymphocytes}</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2009</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/19638417</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">11</style></number><volume><style face="normal" font="default" size="100%">64</style></volume><pages><style face="normal" font="default" size="100%">1107–1113</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Calorie restriction {(CR)} enhances immune response and prolongs life span in animals. However, information on the applicability of these results to humans is limited. T-cell function declines with age. We examined effects of {CR} on T-cell function in humans. Forty-six overweight, nonobese participants aged 20-42 years were randomly assigned to 30% or 10% {CR} group for 6 months. Delayed-type hypersensitivity {(DTH),} T-cell proliferation {(TP),} and prostaglandin E(2) {(PGE(2))} productions were determined before and after {CR.} {DTH} and {TP} to T-cell mitogens were increased in both groups over baseline (p {\textless} or = .019). However, number of positive responses to {DTH} antigens (p = .016) and {TP} to {anti-CD3} reached statistical significance only after 30% {CR} (p = .001). Lipopolysaccharide-stimulated {PGE(2)} was reduced in both groups but reached statistical significance after 30% {CR} (p {\textless} or = .029). These results, for the first time, show that 6-month {CR} in humans improves T-cell function.</style></abstract><notes><style face="normal" font="default" size="100%">{PMID:} 19638417</style></notes></record></records></xml>