<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">M K Shea</style></author><author><style face="normal" font="default" size="100%">E J Benjamin</style></author><author><style face="normal" font="default" size="100%">J Dupuis</style></author><author><style face="normal" font="default" size="100%">J M Massaro</style></author><author><style face="normal" font="default" size="100%">Paul F. Jacques</style></author><author><style face="normal" font="default" size="100%">R B {D'Agostino}</style></author><author><style face="normal" font="default" size="100%">Jose M Ordovas</style></author><author><style face="normal" font="default" size="100%">C J {O'Donnell}</style></author><author><style face="normal" font="default" size="100%">Bess {Dawson-Hughes}</style></author><author><style face="normal" font="default" size="100%">R S Vasan</style></author><author><style face="normal" font="default" size="100%">Sarah L Booth</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Genetic and non-genetic correlates of vitamins K and D</style></title><secondary-title><style face="normal" font="default" size="100%">European Journal of Clinical Nutrition</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Age Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Biological Markers</style></keyword><keyword><style  face="normal" font="default" size="100%">Creatinine</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Linkage</style></keyword><keyword><style  face="normal" font="default" size="100%">Heritable</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypertension</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypolipidemic Agents</style></keyword><keyword><style  face="normal" font="default" size="100%">lipids</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Menopause</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Osteocalcin</style></keyword><keyword><style  face="normal" font="default" size="100%">Quantitative Trait</style></keyword><keyword><style  face="normal" font="default" size="100%">Smoking</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin D</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin K</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin K 1</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamins</style></keyword><keyword><style  face="normal" font="default" size="100%">Waist Circumference</style></keyword><keyword><style  face="normal" font="default" size="100%">{Cross-Sectional} Studies</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">04/2009</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/18030310</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">4</style></number><volume><style face="normal" font="default" size="100%">63</style></volume><pages><style face="normal" font="default" size="100%">458–464</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">To assess the genetic and nongenetic correlates of circulating measures of vitamins K and D status in a community-based sample of men and women.

A cross-sectional study of 1762 participants of the Framingham Offspring Study (919 women; mean age 59 years). Vitamin K status was measured as plasma phylloquinone and serum percent undercarboxylated osteocalcin {(ucOC),} and vitamin D was measured using plasma 25-hydroxyvitamin D {(25(OH)D).} Associations between vitamin K status and vitamin D status with biologically plausible nongenetic factors were assessed using stepwise regression. Heritability and linkage were determined using Sequential Oligogenic Linkage Analysis Routines (SOLAR).

Nongenetic factors accounted for 20.1 and 12.3% of the variability in plasma phylloquinone in men and women respectively, with triglycerides and phylloquinone intake being the primary correlates. In men 12.2% and in women 14.6% of the variability in {%ucOC} was explained by nongenetic factors in our models. Heritability estimates for these vitamin K status biomarkers were nonsignificant. Season, vitamin D intake, high-density lipoprotein {(HDL)} cholesterol and waist circumference explained 24.7% (men) and 24.2% (women) of the variability in plasma {25(OH)D.} Of the three vitamins examined, only {25(OH)D} was significantly heritable (heritability estimate=28.8%, P&amp;lt;0.01), but linkage analysis of {25(OH)D} did not achieve genome-wide significance.

Variability in biomarkers of vitamin K status was attributed to nongenetic factors, whereas plasma {25(OH)D} was found to be significantly heritable. Further studies are warranted to investigate genetic loci influencing vitamin D status.</style></abstract><notes><style face="normal" font="default" size="100%">{PMID:} 18030310</style></notes></record></records></xml>