<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rachel M Holden</style></author><author><style face="normal" font="default" size="100%">A Ross Morton</style></author><author><style face="normal" font="default" size="100%">Jocelyn S Garland</style></author><author><style face="normal" font="default" size="100%">Andrey Pavlov</style></author><author><style face="normal" font="default" size="100%">Andrew G Day</style></author><author><style face="normal" font="default" size="100%">Sarah L Booth</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Vitamins K and D status in stages 3-5 chronic kidney disease</style></title><secondary-title><style face="normal" font="default" size="100%">Clinical Journal of the American Society of Nephrology: {CJASN}</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">80 and over</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Apolipoproteins E</style></keyword><keyword><style  face="normal" font="default" size="100%">Biological Markers</style></keyword><keyword><style  face="normal" font="default" size="100%">Chronic Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">diet</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Markers</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney Diseases</style></keyword><keyword><style  face="normal" font="default" size="100%">Linear Models</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Mixed Function Oxygenases</style></keyword><keyword><style  face="normal" font="default" size="100%">Nutritional Status</style></keyword><keyword><style  face="normal" font="default" size="100%">Osteocalcin</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Precursors</style></keyword><keyword><style  face="normal" font="default" size="100%">Proteinuria</style></keyword><keyword><style  face="normal" font="default" size="100%">Prothrombin</style></keyword><keyword><style  face="normal" font="default" size="100%">Single Nucleotide</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin D</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin D Deficiency</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin K</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin K 1</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin K Deficiency</style></keyword><keyword><style  face="normal" font="default" size="100%">Young Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">{Cross-Sectional} Studies</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2010</style></year><pub-dates><date><style  face="normal" font="default" size="100%">04/2010</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/20167683</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">4</style></number><volume><style face="normal" font="default" size="100%">5</style></volume><pages><style face="normal" font="default" size="100%">590–597</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Vitamin K, vitamin K-dependent proteins, and vitamin D may be involved in the regulation of calcification in chronic kidney disease (CKD).

Vitamin K and D status was measured as dietary intake, plasma phylloquinone, serum percent uncarboxylated osteocalcin {(%ucOC),} proteins induced by vitamin K absence {(PIVKA-II),} Vitamin K Epoxide Reductase single-nucleotide polymorphism, apolipoprotein E genotype, and plasma 25-hydroxyvitamin D {(25(OH)D)} in 172 subjects with stage 3 to 5 {CKD.} Nutritional status was determined by subjective global assessment.

Subclinical vitamin K deficiency criteria was met by 6% (phylloquinone), 60% {(%ucOC),} and 97% {(PIVKA-II)} of subjects, whereas 58.3% and 8.6% had {25(OH)D} insufficiency and deficiency, respectively. Dietary vitamin K intake was associated with higher phylloquinone and lower {PIVKA-II.} There were positive correlations between phylloquinone and the presence of stable weight, and the absence of subcutaneous fat loss or muscle wasting. {25(OH)D} levels were positively associated with stable weight and albumin {(P} &amp;lt; 0.001). {PIVKA-II} levels were associated with apolipoprotein E genotype. Higher {%ucOC} and lower {25(OH)D} were similarly associated with {CKD} stage, parameters of mineral metabolism, and urine albumin to creatinine ratio.

These data indicate that a suboptimal vitamin K and D status is prevalent in patients with {CKD.} Sufficiency of both vitamins K and D was similarly predicted by measures of overall improved nutritional status. Proteinuria was associated with both a suboptimal vitamin D status as well as worse peripheral vitamin K status.</style></abstract><notes><style face="normal" font="default" size="100%">{PMID:} 20167683</style></notes></record></records></xml>