<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Susan Cheng</style></author><author><style face="normal" font="default" size="100%">Joseph M Massaro</style></author><author><style face="normal" font="default" size="100%">Caroline S Fox</style></author><author><style face="normal" font="default" size="100%">Martin G Larson</style></author><author><style face="normal" font="default" size="100%">Michelle J Keyes</style></author><author><style face="normal" font="default" size="100%">Elizabeth L {McCabe}</style></author><author><style face="normal" font="default" size="100%">Sander J Robins</style></author><author><style face="normal" font="default" size="100%">Christopher J {O'Donnell}</style></author><author><style face="normal" font="default" size="100%">Udo Hoffmann</style></author><author><style face="normal" font="default" size="100%">Paul F. Jacques</style></author><author><style face="normal" font="default" size="100%">Sarah L Booth</style></author><author><style face="normal" font="default" size="100%">Ramachandran S Vasan</style></author><author><style face="normal" font="default" size="100%">Myles Wolf</style></author><author><style face="normal" font="default" size="100%">Thomas J Wang</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study</style></title><secondary-title><style face="normal" font="default" size="100%">Diabetes</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Abdominal Fat</style></keyword><keyword><style  face="normal" font="default" size="100%">Adipose Tissue</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Blood Pressure</style></keyword><keyword><style  face="normal" font="default" size="100%">Cardiovascular Diseases</style></keyword><keyword><style  face="normal" font="default" size="100%">Cholesterol</style></keyword><keyword><style  face="normal" font="default" size="100%">European Continental Ancestry Group</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucose Intolerance</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypertension</style></keyword><keyword><style  face="normal" font="default" size="100%">Longitudinal Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity</style></keyword><keyword><style  face="normal" font="default" size="100%">Tomography</style></keyword><keyword><style  face="normal" font="default" size="100%">Triglycerides</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin D</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin D Deficiency</style></keyword><keyword><style  face="normal" font="default" size="100%">{HDL</style></keyword><keyword><style  face="normal" font="default" size="100%">{X-Ray} Computed</style></keyword><keyword><style  face="normal" font="default" size="100%">} Cohort Studies</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2010</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2010</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/19833894</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">1</style></number><volume><style face="normal" font="default" size="100%">59</style></volume><pages><style face="normal" font="default" size="100%">242–248</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Because vitamin D deficiency is associated with a variety of chronic diseases, understanding the characteristics that promote vitamin D deficiency in otherwise healthy adults could have important clinical implications. Few studies relating vitamin D deficiency to obesity have included direct measures of adiposity. Furthermore, the degree to which vitamin D is associated with metabolic traits after adjusting for adiposity measures is unclear.

We investigated the relations of serum 25-hydroxyvitamin D {(25[OH]D)} concentrations with indexes of cardiometabolic risk in 3,890 nondiabetic individuals; 1,882 had subcutaneous adipose tissue {(SAT)} and visceral adipose tissue {(VAT)} volumes measured by multidetector computed tomography (CT).

In multivariable-adjusted regression models, {25(OH)D} was inversely associated with winter season, waist circumference, and serum insulin {(P} &amp;lt; 0.005 for all). In models further adjusted for {CT} measures, {25(OH)D} was inversely related to {SAT} (-1.1 ng/ml per {SD} increment in {SAT,} P = 0.016) and {VAT} (-2.3 ng/ml per {SD,} P &amp;lt; 0.0001). The association of {25(OH)D} with insulin resistance measures became nonsignificant after adjustment for {VAT.} Higher adiposity volumes were correlated with lower {25(OH)D} across different categories of {BMI,} including in lean individuals {(BMI} &amp;lt;25 kg/m(2)). The prevalence of vitamin D deficiency {(25[OH]D} &amp;lt;20 ng/ml) was threefold higher in those with high {SAT} and high {VAT} than in those with low {SAT} and low {VAT} {(P} &amp;lt; 0.0001).

Vitamin D status is strongly associated with variation in subcutaneous and especially visceral adiposity. The mechanisms by which adiposity promotes vitamin D deficiency warrant further study.</style></abstract><notes><style face="normal" font="default" size="100%">{PMID:} 19833894</style></notes></record></records></xml>