<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jian Shen</style></author><author><style face="normal" font="default" size="100%">Donna K Arnett</style></author><author><style face="normal" font="default" size="100%">Laurence D Parnell</style></author><author><style face="normal" font="default" size="100%">Lai, {Chao-Qiang}</style></author><author><style face="normal" font="default" size="100%">Robert J Straka</style></author><author><style face="normal" font="default" size="100%">Hopkins, Paul N</style></author><author><style face="normal" font="default" size="100%">An, Ping</style></author><author><style face="normal" font="default" size="100%">Feitosa, Mary F</style></author><author><style face="normal" font="default" size="100%">Jose M Ordovas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Cardiovascular Pharmacology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">11/2011</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/22075751</style></url></web-urls></urls><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">CYP7A1 encodes cholesterol 7α-hydroxylase an enzyme crucial to cholesterol homeostasis. Its transcriptional activity is down-regulated by fenofibrate. The goal of this study was to determine the effect of CYP7A1 polymorphisms on lipid changes in response to fenofibrate. We examined associations of three tagging single nuclear polymorphisms (SNP) (i6782C&gt;T, m204T&gt;G, 3U12536A&gt;C) at CYP7A1 with triglyceride (TG) and HDL-C responses to a 3-week treatment with fenofibrate 160 mg/d in 864 US White participants from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study. The m204T&gt;G variant significantly associated TG and HDL-C responses to fenofibrate. Individual homozygous for the common T allele of m204T&gt;G SNP displayed both the greater reduction of TG (-32% for TT, -28% for GT, -25% for GG</style></abstract><notes><style face="normal" font="default" size="100%">{PMID:} 22075751</style></notes></record></records></xml>