<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ann R Falsey</style></author><author><style face="normal" font="default" size="100%">Gerard E Dallal</style></author><author><style face="normal" font="default" size="100%">Maria A Formica</style></author><author><style face="normal" font="default" size="100%">Gloria G Andolina</style></author><author><style face="normal" font="default" size="100%">Davidson H Hamer</style></author><author><style face="normal" font="default" size="100%">Lynette L Leka</style></author><author><style face="normal" font="default" size="100%">Simin Nikbin Meydani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Long-term care facilities: a cornucopia of viral pathogens</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of the American Geriatrics Society</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">80 and over</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibodies</style></keyword><keyword><style  face="normal" font="default" size="100%">Boston</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunoenzyme Techniques</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Metapneumovirus</style></keyword><keyword><style  face="normal" font="default" size="100%">Nursing Homes</style></keyword><keyword><style  face="normal" font="default" size="100%">Paramyxoviridae Infections</style></keyword><keyword><style  face="normal" font="default" size="100%">Respiratory Tract Infections</style></keyword><keyword><style  face="normal" font="default" size="100%">Viral</style></keyword><keyword><style  face="normal" font="default" size="100%">Viruses</style></keyword><keyword><style  face="normal" font="default" size="100%">{Long-Term} Care</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2008</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/18557966</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">7</style></number><volume><style face="normal" font="default" size="100%">56</style></volume><pages><style face="normal" font="default" size="100%">1281–1285</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">OBJECTIVES To determine the frequency and types of respiratory viruses circulating in Boston long-term care facilities (LTCFs) during a 3-year period.
DESIGN Observational.
SETTING Thirty-three Boston-area LTCFs over a 3-year period.
PARTICIPANTS Residents of long-term care who had previously participated in a trial of vitamin E supplementation and had paired serum samples available for viral analysis.
MEASUREMENTS Viral antibody titers to eight respiratory viruses (influenza A and B, respiratory syncytial virus (RSV), parainfluenza virus serotype three (PIV-3), PIV-2, human metapneumovirus (hMPV), and coronaviruses 229E and {OC43) were measured using enzyme immunoassay at baseline and 53 weeks. Infection was defined as a more than quadrupling of viral titers. Clinical data on respiratory illnesses were collected throughout the study period.
RESULTS A total of 617 persons were enrolled in the trial. Of these, 382 (62%) had sera available for viral analysis. A total of 204 viral infections were documented in 157 subjects. Serological responses to all eight viruses were documented, with {hMPV} (12.8%) and coronavirus {229E} (10.5%) being the most common and {PIV-2} (2.4%) the least common. The occurrence of bronchitis (P=.007), pneumonia (P=.02), and any lower respiratory tract infection (P=.002) was significantly associated with having a viral diagnosis.
CONCLUSION A wide range of respiratory viruses cocirculates in LTCFs and contributes to respiratory illness morbidity in these populations.</style></abstract><notes><style face="normal" font="default" size="100%">{PMID:} 18557966</style></notes></record></records></xml>