<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Suzanne E Dorfman</style></author><author><style face="normal" font="default" size="100%">Shu Wang</style></author><author><style face="normal" font="default" size="100%">Sonia {Vega-López}</style></author><author><style face="normal" font="default" size="100%">Matti Jauhiainen</style></author><author><style face="normal" font="default" size="100%">Alice H Lichtenstein</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Dietary fatty acids and cholesterol differentially modulate {HDL} cholesterol metabolism in {Golden-Syrian} hamsters</style></title><secondary-title><style face="normal" font="default" size="100%">The Journal of Nutrition</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Apolipoprotein {A-I</style></keyword><keyword><style  face="normal" font="default" size="100%">Cholesterol</style></keyword><keyword><style  face="normal" font="default" size="100%">Dietary</style></keyword><keyword><style  face="normal" font="default" size="100%">Dietary Fats</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipoproteins</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Mesocricetus</style></keyword><keyword><style  face="normal" font="default" size="100%">Triglycerides</style></keyword><keyword><style  face="normal" font="default" size="100%">{HDL</style></keyword><keyword><style  face="normal" font="default" size="100%">{Phosphatidylcholine-Sterol} {O-Acyltransferase</style></keyword><keyword><style  face="normal" font="default" size="100%">} Butter</style></keyword><keyword><style  face="normal" font="default" size="100%">} Cricetinae</style></keyword><keyword><style  face="normal" font="default" size="100%">} Polymerase Chain Reaction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2005</style></year><pub-dates><date><style  face="normal" font="default" size="100%">mar</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/15735083</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">3</style></number><volume><style face="normal" font="default" size="100%">135</style></volume><pages><style face="normal" font="default" size="100%">492–498</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Dietary fatty acids alter {HDL} cholesterol concentrations, presumably through mechanisms related to reverse cholesterol transport. The effect of dietary fats (coconut oil, butter, traditional stick margarine, soybean oil, canola oil) differing in fatty acid profile on this antiatherogenic process was assessed with respect to plasma lipids; exogenous and endogenous lecithin-cholesterol acyltransferase {(LCAT),} cholesterol ester transfer protein {(CETP),} phospholipid transfer protein {(PLTP)} activities; and {LCAT,} apolipoprotein (apo) {A-I} and scavenger receptor B class-1 {(SR-B1)} {mRNA} abundance. {Golden-Syrian} hamsters were fed a nonpurified (6.25 g/100 g fat) diet containing an additional 10 g/100 g experimental fat and 0.1 g/100 g cholesterol for 6 wk. Canola and soybean oils significantly lowered serum {HDL} cholesterol concentrations relative to butter. Canola oil, relative to butter, resulted in higher exogenous {LCAT} activity, and both soybean and canola oils significantly increased hepatic apo {A-I} and {SR-B1} {mRNA} abundance. Butter, relative to margarine, coconut and soybean oils, significantly increased serum {non-HDL} cholesterol concentrations. Endogenous and exogenous {LCAT,} {CETP,} and {PLTP} activities did not differ in hamsters fed margarine or saturated fat diets, despite lower hepatic {LCAT,} apo {A-I,} and {SR-B1} {mRNA} abundance, suggesting that changes in available substrate and/or modification to the {LCAT} protein may have been involved in lipoprotein changes. These results suggest that lower {HDL} cholesterol concentrations, as a result of canola and soybean oil feeding, may not be detrimental due to increases in components involved in the reverse cholesterol transport process in these hamsters and may retard the progression of atherosclerosis.</style></abstract><notes><style face="normal" font="default" size="100%">{PMID:} 15735083</style></notes></record></records></xml>