<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul F. Jacques</style></author><author><style face="normal" font="default" size="100%">Allen Taylor</style></author><author><style face="normal" font="default" size="100%">Suzen Moeller</style></author><author><style face="normal" font="default" size="100%">Susan E Hankinson</style></author><author><style face="normal" font="default" size="100%">Gail Rogers</style></author><author><style face="normal" font="default" size="100%">William Tung</style></author><author><style face="normal" font="default" size="100%">José Ludovico</style></author><author><style face="normal" font="default" size="100%">Walter C Willett</style></author><author><style face="normal" font="default" size="100%">Leo T Chylack</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Long-term nutrient intake and 5-year change in nuclear lens opacities</style></title><secondary-title><style face="normal" font="default" size="100%">Archives of Ophthalmology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Cataract</style></keyword><keyword><style  face="normal" font="default" size="100%">Crystalline</style></keyword><keyword><style  face="normal" font="default" size="100%">Diet Records</style></keyword><keyword><style  face="normal" font="default" size="100%">Diet Surveys</style></keyword><keyword><style  face="normal" font="default" size="100%">Dietary Supplements</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Image Processing</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Nutrition Assessment</style></keyword><keyword><style  face="normal" font="default" size="100%">Questionnaires</style></keyword><keyword><style  face="normal" font="default" size="100%">Riboflavin</style></keyword><keyword><style  face="normal" font="default" size="100%">Thiamine</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin E</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamins</style></keyword><keyword><style  face="normal" font="default" size="100%">Women's Health</style></keyword><keyword><style  face="normal" font="default" size="100%">{Computer-Assisted</style></keyword><keyword><style  face="normal" font="default" size="100%">} Lens Nucleus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2005</style></year><pub-dates><date><style  face="normal" font="default" size="100%">04/2005</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/15824226</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">4</style></number><volume><style face="normal" font="default" size="100%">123</style></volume><pages><style face="normal" font="default" size="100%">517–526</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">OBJECTIVE To determine if usual nutrient intake is related to a 5-year change in the amount of lens nuclear opacification assessed by computer-assisted image analysis.
DESIGN A sample of 408 Boston, Mass-area women from the Nurses' Health Study aged 52 to 74 years at baseline participated in a 5-year study related to nutrition and vision. Usual nutrient intake was calculated as the average intake from 5 food frequency questionnaires that were collected over a 13- to 15-year period before the baseline evaluation of lens nuclear density. Duration of vitamin supplement use before baseline was determined from 7 questionnaires collected during this same period. We assessed the degree of nuclear density (opacification) using computer-assisted image analysis of digital lens images with amount of nuclear density measured as a function of average pixel gray scale, ranging from 0 (clear) to 255 (black).
RESULTS Median (range) baseline and follow-up nuclear densities were 44 (19 to 102) and 63 (32 to 213). The median (range) 5-year change in nuclear density was 18 (-29 to 134) and was positively correlated with the amount of opacification at baseline {(Spearman} correlation coefficient = 0.35; P&amp;lt;.001). Geometric mean 5-year change in nuclear density was inversely associated with the intake of riboflavin {(P} trend = .03) and thiamin {(P} trend = .04) and duration of vitamin E supplement use {(P} trend = .006).
CONCLUSION Our results suggest that long-term use of vitamin E supplements and higher riboflavin and/or thiamin intake may reduce the progression of age-related lens opacification.</style></abstract><notes><style face="normal" font="default" size="100%">{PMID:} 15824226</style></notes></record></records></xml>