<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nicole H Rogers</style></author><author><style face="normal" font="default" size="100%">James W Perfield</style></author><author><style face="normal" font="default" size="100%">Katherine J Strissel</style></author><author><style face="normal" font="default" size="100%">Martin S Obin</style></author><author><style face="normal" font="default" size="100%">Andrew S Greenberg</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity</style></title><secondary-title><style face="normal" font="default" size="100%">Endocrinology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adipose Tissue</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Body Fat Distribution</style></keyword><keyword><style  face="normal" font="default" size="100%">Body Weight</style></keyword><keyword><style  face="normal" font="default" size="100%">Energy Intake</style></keyword><keyword><style  face="normal" font="default" size="100%">Energy Metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Fasting</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Inbred {C57BL</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity</style></keyword><keyword><style  face="normal" font="default" size="100%">Organ Size</style></keyword><keyword><style  face="normal" font="default" size="100%">Ovariectomy</style></keyword><keyword><style  face="normal" font="default" size="100%">Time Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Uterus</style></keyword><keyword><style  face="normal" font="default" size="100%">} Motor Activity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">05/2009</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/19179442</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">5</style></number><volume><style face="normal" font="default" size="100%">150</style></volume><pages><style face="normal" font="default" size="100%">2161–2168</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Menopause, an age-related loss of ovarian hormone production, promotes increased adiposity and insulin resistance. However, the diet-independent mechanism by which loss of ovarian function promotes increased adipose tissue mass and associated metabolic pathologies remains unclear. To address this question, we monitored food intake and weight gain of ovariectomized {(OVX)} mice and sham OVX {(SHM)} mice for 12 wk. Although food intake was similar, {OVX} mice gained 25% more weight than {SHM} mice. Moreover, the {OVX} mice accumulated 4.7- and 4.4-fold more perigonadal and inguinal adipose tissue by weight, respectively, with 4.4-fold (perigonadal, P  0.001) and 5.3-fold (inguinal, P  0.01) larger adipocytes and no change in adipocyte cell number. {OVX-induced} adiposity was coincident with an 18% decrease in metabolic rate during the dark phase {(P} = 0.001) as well as an 11% decrease during the light phase (P = 0.03). In addition, ambulatory activity levels of {OVX} mice were decreased only during the dark phase (40%</style></abstract><notes><style face="normal" font="default" size="100%">{PMID:} 19179442</style></notes></record></records></xml>