<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Saverio Cinti</style></author><author><style face="normal" font="default" size="100%">Grant Mitchell</style></author><author><style face="normal" font="default" size="100%">Giorgio Barbatelli</style></author><author><style face="normal" font="default" size="100%">Incoronata Murano</style></author><author><style face="normal" font="default" size="100%">Enzo Ceresi</style></author><author><style face="normal" font="default" size="100%">Emanuela Faloia</style></author><author><style face="normal" font="default" size="100%">Shupei Wang</style></author><author><style face="normal" font="default" size="100%">Melanie Fortier</style></author><author><style face="normal" font="default" size="100%">Andrew S Greenberg</style></author><author><style face="normal" font="default" size="100%">Martin S Obin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Lipid Research</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adipocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Adipose Tissue</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Death</style></keyword><keyword><style  face="normal" font="default" size="100%">Crosses</style></keyword><keyword><style  face="normal" font="default" size="100%">Electron</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression Regulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Giant Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypertrophy</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunohistochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Inbred {C57BL</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin Resistance</style></keyword><keyword><style  face="normal" font="default" size="100%">Macrophages</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Microscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Necrosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Obese</style></keyword><keyword><style  face="normal" font="default" size="100%">Species Specificity</style></keyword><keyword><style  face="normal" font="default" size="100%">Sterol Esterase</style></keyword><keyword><style  face="normal" font="default" size="100%">Time Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Transgenic</style></keyword><keyword><style  face="normal" font="default" size="100%">} Mice</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2005</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/16150820</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">11</style></number><volume><style face="normal" font="default" size="100%">46</style></volume><pages><style face="normal" font="default" size="100%">2347–2355</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Macrophage infiltration of white adipose tissue {(WAT)} is implicated in the metabolic complications of obesity. The precipitating event(s) and function(s) of macrophage infiltration into {WAT} are unknown. We demonstrate that {\textgreater}90% of all macrophages in {WAT} of obese mice and humans are localized to dead adipocytes, where they fuse to form syncytia that sequester and scavenge the residual &quot;free&quot; adipocyte lipid droplet and ultimately form multinucleate giant cells, a hallmark of chronic inflammation. Adipocyte death increases in obese (db/db) mice (30-fold) and humans and exhibits ultrastructural features of necrosis (but not apoptosis). These observations identify necrotic-like adipocyte death as a pathologic hallmark of obesity and suggest that scavenging of adipocyte debris is an important function of {WAT} macrophages in obese individuals. The frequency of adipocyte death is positively correlated with increased adipocyte size in obese mice and humans and in hormone-sensitive lipase-deficient {(HSL-/-)} mice, a model of adipocyte hypertrophy without increased adipose mass. {WAT} of {HSL-/-} mice exhibited a 15-fold increase in necrotic-like adipocyte death and formation of macrophage syncytia, coincident with increased tumor necrosis factor-alpha gene expression. These results provide a novel framework for understanding macrophage recruitment, function, and persistence in {WAT} of obese individuals.</style></abstract><notes><style face="normal" font="default" size="100%">{PMID:} 16150820</style></notes></record></records></xml>