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Faculty Member: 
Ausman
Choi
Russell
Wang
TitleHigh dose lycopene supplementation increases hepatic cytochrome P4502E1 protein and inflammation in alcohol-fed rats
Publication TypeJournal Article
Year of Publication2008
AuthorsVeeramachaneni S, Ausman LM, Choi S-W, Russell RM, Wang X-D
JournalThe Journal of Nutrition
Volume138
Pagination1329–1335
Date Published07/2008
ISSN1541-6100
KeywordsAlcoholism, Animals, Antioxidants, Carotenoids, Cytochrome P-450 {CYP2E1, Drug, Inbred F344, Inflammation, Liver, Male, Organ Size, Rats, Tumor Necrosis Factor-alpha, {Dose-Response} Relationship, {RNA, } Dietary Supplements, } Messenger
Abstract

Recent in vitro evidence suggests that the antioxidant lycopene can prevent alcohol-induced oxidative stress and inflammation. However, knowledge of possible interactions in vivo between escalating doses of lycopene and chronic alcohol ingestion are lacking. In this study, we investigated potential interactions between alcohol ingestion and lycopene supplementation and their effect on hepatic lycopene concentration, cytochrome P4502E1 (CYP2E1) induction, and inflammation. Fischer 344 rats (6 groups
URLhttp://www.ncbi.nlm.nih.gov/pubmed/18567756