Effects of cranberry juice consumption on vascular function in patients with coronary artery disease

{{{\textless}AbstractText} {Label="BACKGROUND"} {NlmCategory="BACKGROUND"{\textgreater}Cranberry} juice contains polyphenolic compounds that could improve endothelial function and reduce cardiovascular disease {risk.{\textless}/AbstractText{\textgreater}} {{\textless}AbstractText} {Label="OBJECTIVE"} {NlmCategory="OBJECTIVE"{\textgreater}The} objective was to examine the effects of cranberry juice on vascular function in subjects with coronary artery {disease.{\textless}/AbstractText{\textgreater}} {{\textless}AbstractText} {Label="DESIGN"} {NlmCategory="METHODS"{\textgreater}We} completed an acute pilot study with no placebo (n = 15) and a chronic placebo-controlled crossover study (n = 44) that examined the effects of cranberry juice on vascular function in subjects with coronary artery {disease.{\textless}/AbstractText{\textgreater}} {{\textless}AbstractText} {Label="RESULTS"} {NlmCategory="RESULTS"{\textgreater}In} the chronic crossover study, subjects with coronary heart disease consumed a research preparation of double-strength cranberry juice (54% juice, 835 mg total polyphenols, and 94 mg anthocyanins) or a matched placebo beverage (480 {mL/d)} for 4 wk each with a 2-wk rest period between beverages. Beverage order was randomly assigned, and participants refrained from consuming other flavonoid-containing beverages during the study. Vascular function was measured before and after each beverage, with follow-up testing ≥12 h after consumption of the last beverage. Mean {(±SD)} carotid-femoral pulse wave velocity, a measure of central aortic stiffness, decreased after cranberry juice (8.3 ± 2.3 to 7.8 ± 2.2 m/s) in contrast with an increase after placebo (8.0 ± 2.0 to 8.4 ± 2.8 m/s) {(P} = 0.003). Brachial artery flow-mediated dilation, digital pulse amplitude tonometry, blood pressure, and carotid-radial pulse wave velocity did not change. In the uncontrolled pilot study, we observed improved brachial artery flow-mediated dilation (7.7 ± 2.9% to 8.7 ± 3.1%