Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: The Framingham Heart Study

{{{\textless}AbstractText} {Label="OBJECTIVE"} {NlmCategory="OBJECTIVE"{\textgreater}To} determine the association of well-characterized lipoprotein-related genetic variants with carotid intimal medial thickness {(IMT)} and {stenosis.{\textless}/AbstractText{\textgreater}} {{\textless}AbstractText} {Label="METHODS"} {NlmCategory="METHODS"{\textgreater}3380} men and women from the Framingham Offspring Study underwent carotid ultrasound to determine carotid {IMT} and stenosis>/=25%. We genotyped 12 variants in 10 lipoprotein-related genes known to be associated with significant differences in lipoprotein {levels.{\textless}/AbstractText{\textgreater}} {{\textless}AbstractText} {Label="RESULTS"} {NlmCategory="RESULTS"{\textgreater}For} most of the variants, there was no association with carotid {IMT.} In multivariable, sex-specific analyses, the rare allele of the cholesterol ester transfer protein {(CETP)} {TaqIB} variant was associated with lower {ICA} {IMT} in men. Hypertension was associated with higher {ICA} {IMT} only in male carriers of the rare allele of the {APOCIII} Sst-1 variant (p for the interaction=0.041). In analyses of carotid stenosis in male, carriers of the lipoprotein lipase {(LPL)} {N291S} rare variant showed a higher risk of carotid stenosis {(OR=2.59,} 95% confidence interval: 1.11-6.02