This course is a perspective from the intersection of food and biology and will build upon principles of energy balance that were developed in Nutritional Biochemistry. In the first section, physiologic regulation of body weight and its dysregulation leading to obesity will be explored. The interaction between hormonal/neuroendocrine systems and dietary factors will featured. In the second half of the course, lifestyle, pharmacologic and surgical approaches to obesity treatment as well as maintenance of lost weight will be presented.